Modasmart 400 should be avoided by individuals with heart conditions, uncontrolled high blood pressure, severe anxiety disorders, liver problems, or a history of substance misuse, as its stimulant-like effects may worsen these conditions. It is also not recommended for pregnant or breastfeeding women, people with hypersensitivity to modafinil or armodafinil, or those taking medications that can interact strongly with it, such as certain antidepressants or hormonal contraceptives. Anyone with underlying medical conditions should consult a healthcare professional before using Modasmart 400.