If you're facing QuickBooks Error 15271, follow these steps to resolve it. First, ensure QuickBooks and any related applications are closed. Next, update QuickBooks by going to Help > Update QuickBooks > Update Now to download the latest updates. Running QuickBooks as an administrator can also help—right-click the QuickBooks icon and select Run as Administrator. Additionally, check for software conflicts, such as with your antivirus, and temporarily disable them if necessary. If the problem continues, try repairing QuickBooks via Control Panel > Programs and Features, select QuickBooks, and choose Repair. For persistent issues, contacting QuickBooks support may be necessary.