Cenforce 130 mg should be taken approximately 30 minutes to 1 hour before engaging in sexual activity. This timeframe allows the medication to be absorbed into the bloodstream and start working effectively. It is important to note that individual responses to medication can vary, so some individuals may experience the effects sooner or later than the typical timeframe. It is recommended to follow the instructions provided by your healthcare provider or the medication's label for the most accurate guidance on when to take Cenforce 130 before sexual activity.